B. Preparation of N,N-Diethyl-m-toluamide Diethylamine hydrochloride irritates the skin, eyes, and respiratory tract. Avoid contact and inhalation. In the reaction mixture, it forms diethylamine, which is corrosive and has toxic vapors. Diethyl ether is extremely flammable and may be harmful if inhaled.
Nov 18, 2013· DEET or N,N-diethyl-m-methylbenzamide has been a primary component of our synthesis . DEET is a topical insect repellent that is widely used to combat mosquitoes, fleas, ticks, flies, and other biting insects in an effort to help prevent the transmission of arthropod-borne illnesses such as malaria and West Nile virus.
Aug 07, 2014· Recent studies suggest that N, N-diethyl-meta-toluamide (DEET) is an acetylcholinesterase inhibitor and that this action may result in neurotoxicity and pose a risk to humans from its use as an insect repellent. We investigated the mode of action of DEET neurotoxicity in order to define the specific neuronal targets related to its acute toxicity in insects and mammals.
N,N-Diethyl-m-Toluamide (DEET). m-toulic acid (200mg, 1.47mmol), and thionyl chloride (0.20 mL, 2.76 mmol) were added to a simple gas trap, which consisted of a septum, Teflon tubing, oven dried reaction tubes, and a damp cotton plug for catching emitting HCl …
DEET (N, N-diethyl-meta-toluamide) is the most effective and broadly used insect repellent, but its mechanism of action is both complex and controversial. Previous work demonstrated that DEET acts .
Aug 07, 2015· The mechanism of how DEET manipulates these molecular targets to induce insect avoidance in the vapor phase is also contested. Two hypotheses are the most likely: DEET activates an innate olfactory neural circuit leading to avoidance of hosts (smell and avoid hypothesis) or DEET has no behavioral effect on its own, but instead acts cooperatively with host odors to drive repellency …
N,N-Diethyl-meta-toluamide, also called DEET (/ d iː t /) or diethyltoluamide, is the most common active ingredient in insect repellents. It is a slightly yellow oil intended to be applied to the skin or to clothing and provides protection against mosquitoes, ticks, fleas, chiggers, leeches and many biting insects.
N,N-Diethyl-m-toluamide Not listed 106-114 mg/L LC50 96 h 71.25 mg/L LC50 96 h EC50 = 67.9 mg/L 5 min Not listed Persistence and Degradability No information available Bioaccumulation/ Accumulation No information available Mobility No information available 13. DISPOSAL CONSIDERATIONS
May 23, 2000· N,N-diethyl-meta-toluamide (DEET) was developed and patented by the U.S. Army in 1946 for use as an insect repellent by military personnel (U.S. EPA, 1980). In 1957, DEET was registered for use by the general public without any restriction on the amount or frequency of application.
N,N-Diethyl-m-toluamide (DEET) was nominated by the National Institute of Environmental Health Sciences (NIEHS) for toxicity and carcinogenicity testing based on its high U.S. production volume and wide spread consumer use in commercial insect repellents.