Calcium-Phosphate Product and Its Significance In CKD. But if Calcium phosphate product is less than 55 then give patient calcium acetate as a phosphate binder. Decide the dose of vitamin D based on PTH level. If it is more than 100 give activated form of vitamin D which is 1-25 dihydroxy vitamin D3.
The calcium phosphate product is utilized in medicine as a means of monitoring the levels of these two minerals in patients with chronic kidney disease, or CKD. The kidney functions to eliminate phosphorous from the body, as well as to resorb the majority of calcium back into blood.
containing phosphate binders versus calcium-free phosphate binders: study characteristics Table S20. Summary table of randomized controlled trials examining the treatment of CKD-MBD with calcium-containing phosphate binders versus calcium-free phosphate binders: study population characteristics Table S21.
phosphate levels > 1.8 mmol/L and elevated calcium x phosphate products (Nichols et al 1990). Lundin et al (1980) first identified an elevated calcium x phosphate product as a predictor of cardiac mortality (along with age at onset of dialysis and sustained hypertension).
Calcium and Phosphate Balance with Kidney Disease What is vitamin D? Vitamin D is important for good health and strong and healthy bones. It is also important for making sure that your muscles, heart, lungs and brain work well and that your body can fight infection. Your body can make its own vitamin D from sunlight. You can also
…elevated calcium-phosphate product. In addition, CKD patients may be in positive calcium balance even if the serum calcium is normal and there is no increase in the calcium-phosphate product…
4.1.6: In adult patients with CKD G3a-G5D receiving phosphate-lowering treatment, we suggest restricting the dose of calcium-based phosphate binders (2B) . In children with CKD G3a-G5D, it is reasonable to base the choice of phosphate-lowering treatment on serum calcium levels (Not Graded) .
Fibroblast growth factor-23 (FGF-23) is a phosphaturic hormone that increases in early chronic kidney disease (CKD) before abnormalities in serum calcium, phosphate, or parathyroid hormone (PTH) become apparent [1,2].
Calcium, phosphate and bones. Dietary phosphate restriction Phosphate binders (to minimise dietary phosphate absorption) 1α(OH) vitamin D (sometimes called activated vitamin D) The goals of therapy in terms of target calcium, phosphate and PTH concentrations, vary with CKD stage. Many renal units have local protocols for the management of CKD-MBD.